Tuesday 13 June 2017

Leo Pruimboom’s research into Coeliac disease

According to BioMed Central, a scientific article about Coeliac disease by Dr Leo Pruimboom in 2016 has been found to be one of the most widely shared articles from the professional journal Journal of Health, Population and Nutrition. We would like to draw your attention again to this interesting article.


Coeliac disease not always evident

Gluten-containing cereals are a main staple food present in the human diet, including wheat, barley and rye. Gluten intake is not only associated with the development of Coeliac disease, but also with various related disorders, including type 1 diabetes, depression and schizophrenia.


However, the intake of gluten doesn’t always result in visible symptoms. Leo Pruimboom: “Until now, a consensus hasn’t been reached about the potential damaging effects on health of gluten intake because there are often no symptoms, even in people with proven Coeliac disease.”


Is it common?

Asymptomatic Coeliac disease is present in the majority of people with Coeliac disease and is characterised by the absence of the classic gluten-intolerance signs, such as diarrhoea, bloating and abdominal pain. Nevertheless, these individuals very often develop diseases that can be related with gluten intake. Why is that?  


“Gluten can be degraded into several morphine-like substances, named gluten exorphins. These compounds have proven opioid effects and could mask the damaging effects of gluten protein on the gastrointestinal lining and function”, says Leo Pruimboom.


Read the entire article

In the scientific article, an explanation is given regarding the mechanism of action underlying asymptomatic Coeliac disease. You can read the entire article free of charge at BioMed Central (in English).